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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIE1
All Species:
23.64
Human Site:
Y875
Identified Species:
47.27
UniProt:
P35590
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35590
NP_005415.1
1138
125090
Y875
A
I
K
M
L
K
E
Y
A
S
E
N
D
H
R
Chimpanzee
Pan troglodytes
XP_001173341
1138
125051
Y875
A
I
K
M
L
K
E
Y
A
S
E
N
D
H
R
Rhesus Macaque
Macaca mulatta
XP_001090483
1164
128010
Y901
A
I
K
M
L
K
E
Y
A
S
E
N
D
H
R
Dog
Lupus familis
XP_539652
1239
135146
Y976
A
I
K
M
L
K
E
Y
A
S
E
N
D
H
R
Cat
Felis silvestris
Mouse
Mus musculus
Q06806
1134
124680
Y871
A
I
K
M
L
K
E
Y
A
S
E
N
D
H
R
Rat
Rattus norvegicus
Q498D6
800
88690
P572
P
P
G
P
D
L
S
P
D
G
P
R
S
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512741
1077
116365
F813
A
V
K
M
L
K
E
F
A
S
E
N
D
H
R
Chicken
Gallus gallus
P18460
806
89712
L578
Y
S
F
D
T
C
K
L
P
E
E
Q
L
T
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
O73791
1116
122343
Y852
A
V
K
R
M
K
D
Y
A
S
Q
D
D
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VBW3
773
86202
D545
L
G
C
C
T
D
K
D
P
T
F
V
I
L
E
Honey Bee
Apis mellifera
XP_396649
796
90178
L568
H
G
N
L
R
D
F
L
R
D
H
R
P
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
S744
P
P
E
E
Y
E
K
S
I
L
L
T
T
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.1
85.6
N.A.
92.5
25.8
N.A.
65.9
25.1
N.A.
44.6
N.A.
22.4
24.7
N.A.
22.8
Protein Similarity:
100
99.8
96.2
88.1
N.A.
95.5
37.9
N.A.
74.3
39.3
N.A.
58.7
N.A.
36
40.3
N.A.
39.1
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
86.6
6.6
N.A.
60
N.A.
0
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
100
13.3
N.A.
93.3
N.A.
13.3
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
0
0
0
0
0
0
0
59
0
0
0
0
0
0
% A
% Cys:
0
0
9
9
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
9
17
9
9
9
9
0
9
59
0
0
% D
% Glu:
0
0
9
9
0
9
50
0
0
9
59
0
0
0
17
% E
% Phe:
0
0
9
0
0
0
9
9
0
0
9
0
0
0
9
% F
% Gly:
0
17
9
0
0
0
0
0
0
9
0
0
0
0
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
9
0
0
59
0
% H
% Ile:
0
42
0
0
0
0
0
0
9
0
0
0
9
0
0
% I
% Lys:
0
0
59
0
0
59
25
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
9
50
9
0
17
0
9
9
0
9
9
0
% L
% Met:
0
0
0
50
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
0
0
50
0
0
0
% N
% Pro:
17
17
0
9
0
0
0
9
17
0
9
0
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
9
% Q
% Arg:
0
0
0
9
9
0
0
0
9
0
0
17
0
0
59
% R
% Ser:
0
9
0
0
0
0
9
9
0
59
0
0
9
25
9
% S
% Thr:
0
0
0
0
17
0
0
0
0
9
0
9
9
9
0
% T
% Val:
0
17
0
0
0
0
0
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _